摘要
内皮细胞乙酰胆碱激活蛋白 (EPA)介导的内皮依赖性血管舒张反应 ,广泛存在于哺乳动物的大小动脉血管。在心血管常见病与多发病中 ,EPA功能发生明显变化。EPA虽然具有经典M受体的某些特征 ,又与M受体不同 ,EPA不被毛果芸香碱激活 ,nmol·L-1阿托品不能取代EPA上乙酰胆碱的结合位点。EPA的内源性配体。
EPA exists wildly in artery vascular endothelium and could be activated by endogenously activated substances and regulate the vascular tone. The endothelium dependent vascular relaxation mediated by EPA has been used for almost 20 years as an indicator of endothelium dysfunction. In many cardio vascular diseases, EPA function was down regulated. The pharmacological profiles of EPA could be characterized by muscarinic properties, as well as non muscarinic properties in selectivity for agonists and antagonists and in binding characteristics. The endogenous ligand, receptor type and molecular pharmacological characteristics of EPA are waiting to be investigated.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2001年第1期1-5,共5页
Chinese Pharmacological Bulletin
基金
国家重点基础研究发展规划项目!G 19980 5 1112
