摘要
目的 :研究丙泊酚对心内传导系统的影响。方法 :病人 2 0例 ,随机分为两组 (n=10 ) ,A组 :丙泊酚 1.5 mg.kg- 1 诱导 ,3.0 mg.kg- 1 .h- 1持续泵注 ;B组 :丙泊酚 2 .0 mg.kg- 1诱导 ,4.0 mg.kg- 1 .h- 1持续泵注。分别在麻醉前、后测定心率 (HR)、窦房传导时间 (SACT)、最大窦房结恢复时间 (SNRTMAX)、校正窦房结恢复时间 (CSNRT)、窦房结恢复时间指数 (SNRTI)、文氏 A- V传导频率 (WB)、P- R间期、QRS波。结果 :两组丙泊酚均使 SACT明显延长 (P<0 .0 1) ,丙泊酚 2 .0 mg.kg- 1 诱导组 ,WB明显提前 (P<0 .0 5 ) ,其他参数无明显改变。结论 :丙泊酚对窦房传导有抑制作用 ,并随剂量增加而加强 ,使 WB明显提前。
Objective:To investigate the effects of propofol on heart conduction system. Methods:Twenty patients were randomly divided into two groups. In group A ( n=10) propofol(1.5 mg·kg -1 ) was first infused and then 3 mg·kg -1 ·h -1 continuous infusion; and in group B ( n= 10) propofol (2 mg·kg -1 ) was first infused, and then 4 mg·kg -1 ·h -1 continuous infusion. Before and after infusion of propofol, HR, SACT, SNRT MAX , CSNRT, SNRTI, WB, P R interval and QRS were monitored. Results:SACT( P <0.01) was lengthened in two groups, and 2 mg·kg -1 of propofol decreased the WB. The others had no significant change. Conclusion:Propofol may have an obvious depression effect on the heart conduction system in a dose dependent manner.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2001年第3期206-207,共2页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省自然科学基金资助项目 ( 798DA970 3 )
