摘要
目的 探讨应用超常规剂量碘油超选择TAE与常规TAE治疗原发性肝癌的疗效 ,并对其进行比较研究。方法 1987年 8月～ 1999年 12月 12年间 2 76例原发性肝癌被分为两组 :治疗组 16 7例 ,应用常规导管或球囊导管超选择至肿瘤供血动脉 ,阻断其血流 ,使注射碘油时不产生逆流 ,将全部动脉肿瘤血管、病变周围正常的细小动脉及肝实质和门静脉分支栓塞 ;对照组 10 9例 ,应用一般导管 ,常规剂量的碘油超选或不超选栓塞肿瘤供血动脉。结果 治疗组中 ,栓塞全部动脉肿瘤血管、病变周围正常的细小动脉及肝实质 16 7例 ,门静脉分支栓塞 10 9例。 1、2、3、4、5年生存率分别为98.8% (16 5 / 16 7)、79.9% (10 7/ 134)、48% (47/ 98)、36 .6 (2 6 / 71)、2 5 .5 % (12 / 4 7) ;对照组中 ,仅栓塞了部分或全部动脉肿瘤血管 ,1、2、3、4、5年生存率分别为 79.9% (87/ 10 9)、45 .5 % (40 / 88)、2 1.3 %、(13/ 6 1)、10 .2 % (5 / 4 9)、3 .1% (1/ 32 )。两组病人 1、2、3、4、5年生存率经统计学处理有极显著差异 (P <0 .0 1-0 .0 0 1) ,两组病人均无严重合并症发生。结论 应用超常规剂量碘油超选择TAE治疗原发性肝癌效果明显好于常规TAE。
Objective To evaluate the efficency of superselective trasarterial embolization (TAE)with ultra routine dose inodized oil and TAE in the treatment of primary hepatic carcinoma.Methods We retrospectively and statistically analysed 276 cases of primary hepatic carcinoma treated with TAE from 1987 to 1999.According to different therapeutic methods,the patients were divided into two groups:therapeutic group (167 cases),who received superselective TAE with ultra routine dose of iodized oil;109 cases in control group were treated with routine TAE.The curative effects of the two groups were evaluated by their survival rates.Results The embolization of the supplying artery of the tumor,small normal artery and hepatic parenchyma around tumor was carried on all the 167 patients of the threapeutic group,of whom 109 received the emblization of hepatic portal vein branches.The 1 ,2 ,3 ,4 ,5 year survival rates were 98.8%,79.9%,48%,36.6%,25.5% respectively.As for patients in the control group,only the embolization of the supplying artery of the tumor was carried out and The 1 ,2 ,3 ,4 ,5 year survival rates were 79.8%(87/109)、45.5%(40/88)、21.3%(13/61)、10.2%(5/49)、3.1%(1/32).No severe damage to the liver and no remarkable complications were found in all the 276 patients.The 1 ,2 ,3 ,4 and 5 year survival rates of patients in both groups were statistically significant (P<0.01-0.001).Conclusions Superselective TAE with ultra routine dose iodized oil shows more significant clinical effect than routine TAE does in the treatment of primary hepatic carcinoma.
出处
《中国肿瘤临床与康复》
2001年第2期85-87,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
肝动脉
栓塞
治疗
原发性肝癌
碘油
hepatic tumor
hepatic artery
embolization
therapeupy
