摘要
用原子吸收光谱计测定使用钙剂后豚鼠的血清和外淋巴中的钙离子浓度。然后用耳蜗铺片的方法对耳蜗动作电位和血清、外淋巴中的钙离子浓度进行观察比较。结果:静脉注射钙剂后外淋巴中的钙离子浓度随着血清中的钙离子浓度升高而升高,并能维持8h左右。钙剂对庆大霉素的耳蜗毒性有防治作用。
The guinea pigs (GF) were injected intramuscularly 5m1/Kg/day of CG,The concentration of[Ca^(++)]in the blood serum and perilymph was measured with atom absorption spetremter (AAS). Theresult showed that the [Ca^(++)]in the perilymph was steadly increasing within 8hrs. When the GP were injected with CG and GM the AP value was in normal rang and the hair cellswere in normal condition,while in the GM group, the hair cells were seriously damaged, and the Apvalue was elevated to 30db. According to this experiment, CG may be the suitable, unharmful drugwhich can be safely used in clinical prevention to avoid GM intoxication of the inner car. As to theclinical use of [Ca^(++)]preparation, we have to make further study and observation in dosage andmethod of using.
出处
《河南医科大学学报》
1991年第2期133-135,共3页
Journal of Henan Medical University
关键词
庆大霉素
葡萄糖酸钙
耳毒性
gentamycin
calcium gluconic
ototoxicity
inner ear
perilymph
