摘要
以水和甲酰胺（ＦＡ）为介质，用毛细管电泳分离吩噻嗪类药物，比较了两者的选择性、柱效和分离度．与水相比，ＦＡ中选择性不同，有利于分离，被分析的物质均获得了较高的分离度；柱效显著提高，都在１×１０５以上。
Separations of phenothiazines, promethazine(PZ), dioxypromethazine(OZ), chlorpromazine(CZ), trifluoperazine(TfZ) and thioridazine(TZ) by capillary electrophoresis in water and FA media were carried out and compared. Thus different selectivity and resolution were observed as media varying from water to FA. Migration order was PZ, OZ, CZ and TZ in water but (TZ+PZ), CZ and OZ in FA, when the same buffer, 25 mmol/L Tris and 25 mmol/L citric acid, was used. It also has been observed that pH has great effect on selectivity both in water and FA and a possible explanation was given. Separation efficiency was higher in FA media than in water because of the permission of high voltage applied. For all separations in FA 30 kV was applied, and when 25 mmol/L Tris was used as buffer, current was only 20 A and complete separation of TZ, CZ, PZ and OZ was achieved with effencicy higher than 35105 theoretical plates for all analytes. The high performance of capillary electrophoresis in FA suggests that FA is an exc
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1999年第6期856-860,共5页
Chemical Journal of Chinese Universities
基金
中国科学院长春应用化学研究所电分析化学开放研究实验室资助
