摘要
１９８８年，Ｓｈａｒｐｌｅｓｓ等［１］发现金鸡纳生物碱（Ｃｉｎｃｈｏｎａａｌｋａｌｏｉｄ）的衍生物对烯烃的不对称双羟基化反应（ＡＤ）具有很高的不对称诱导活性，反应式如下：Ｒ１Ｒ２ＯｓＯ４／Ｌ＊Ｋ３Ｆｅ（ＣＮ）６／Ｋ２ＣＯ３→ＨＯ＊Ｒ１＊Ｒ２ＯＨ烯烃的...
Bis(9Oquininyl)isophthalate(BQIP) was synthesized from quinine and isophthaloyl dichloride directly. High enantioselectivity and reactivity have been achieved in asymmetric dihydroxylation of transstilbene using BQIP as catalyst(optical yield: 99%), and lower enantioselectivity to styrene was obtained(optical yield: 84.3%). It can be deduced that the chiral cage in BQIP could bind transstilbene more firmly than styrene. Low reaction temperature brought about higher enantioselectivity than that of the high one.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1999年第6期900-902,共3页
Chemical Journal of Chinese Universities
基金
教育部博士点基金
关键词
双奎宁基间苯二甲醇
合成
催化反应
烯烃
不对称双羟基化
Bis(9Oquininyl)isophthalate(BQIP), Asymmetric dihydroxylation of olefins, Catalysis olefin
