摘要
目的和方法：观察应用６５４－２和肠道吸附剂治疗油酸造成兔呼吸窘迫综合征（ＲＤＳ）时左心室功能的变化。结果：（１）油酸组６０和９０ｍｉｎ时左心室功能明显低于对照组（Ｐ＜０．０１）；（２）６５４－２组和肠道吸附剂组左心室功能显著高于油酸组（Ｐ＜０．０５和Ｐ＜０．０１）；（３）油酸组９０ｍｉｎ时血浆和肺泡灌洗液中的中分子物质浓度明显高于对照组（Ｐ＜０．０１），而６５４－２或肠道吸附剂均可明显减少油酸所致的中分子物质的增多（Ｐ＜０．０１）。结论：ＲＤＳ过程可使左心功能降低，而６５４－２或肠道吸附剂均可防治左心功能的降低。
AIM: Dynamic changes of cardiac function during pulmonary injury induced by oleic acid(OA) were studied.METHODS:The animal were treated with 654-2 or enterosorbent and found out a probable mechanism of cardiac function change.RESULTS:(1)Left ventricular function (LVF) at 60min and 90min of OA group was lower than control group.(2)LVF of 654-2+OA group or enterosorbent+OA group was higher than OA group (3) At 90min middle molecular substances(MMS) content in plasma and BALF of OA group was higher that control group. However MMS in 654-2+OA group or enterosorbent group was lower than OA group CONCLUSION:The respiratory distress syndrome(RDS) could decrease cardiac function and 654-2 or enterosorbent could protect decreasing of cardiac function during RDS. Meanwhile there is relations between the changes of cardiac function and MMS content.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1998年第2期166-169,共4页
Chinese Journal of Pathophysiology
