摘要
目的 :制备阿苯达唑 β 环糊精包合物 ,考察了有关性质。方法 :采用逆向搅拌法制备阿苯达唑的 β 环糊精包合物 ,用紫外分光光度法测定阿苯达唑、包合物的溶解度、溶出度。结果 :经空白对照、X 射线衍射图谱、差示扫描量热等方法证明 ,阿苯达唑与 β 环糊精已形成包合物 ,包合物的溶解度是原药的 10倍 ,溶出度明显高于阿苯达唑原药。结论 :阿苯达唑 β 环糊精包合物可提高阿苯达唑的溶解度、溶出度。
OBJECTIVE:To prepare the inclusion compound of albendazole β CD and investigate its properties METHODS:Using test of counter mixture stirring to prepare albendazole β CD The solubility and dissolution rate of inclusion compound and albendazole were measured by UV spectrophotometry RESULTS:The inclusion compound of albendazole β CD was confirmed by blank contrast test, X ray diffraction and differential scanning Its solubility was ten times as high as that of albendazole, and its dissolution rate higher than that of albendazole obviously CONCLUSION:The solubility and dissolution rate of albendazole were increased when the drug was included by β CD
出处
《华西药学杂志》
CAS
CSCD
2001年第2期109-111,共3页
West China Journal of Pharmaceutical Sciences
