摘要
采用６０Ｃｏ与深部Ｘ线两种放射源按１周内１０００ｃＧｙ×４次，８００ｃＧｙ×４次，６００ｃＧｙ×４次，４００ｃＧｙ×４次的剂量分割条件对１２８只豚鼠右侧颌骨照射。于放疗后１，３，５月拔牙，定期进行颌骨微血管铸型检测。结果发现照射后１月毛细血管网络中断，数目减少，小静脉属支继发萎缩；而小动脉病理改变不明显。说明毛细血管是颌骨血管系统中放射敏感性最高的部分；同时在拔牙创不愈的铸型标本局部血管网络缺失，周边可见毛细血管灶性增殖。
In the experiment, both 180 kV Xray and cobalt60 radiation were delivered to right mandibles of 128 guineapigs with different dose (1000 cGy×4, 800 cGy×4, 600 cGy×4, 400 cGy×4 within 1 week). Dental extractions were conducted 1,3,5 months after radiation and the irradiated animals were examined by using microvascular corrosion castings of mandibles. It was found that the number of capillaries reduced and microvascular networks broke off after radiation with small veins shrinking subsequently while the alterations of arteries were slight. This result indicated that capillary was the most vulnerable part to the damage of radiation in the vascular system. In addition the defects of vascular networks around the nonhealing tooth extraction sites were also discovered with irregularly capillary proliferation in the periphery of the lesion. The phenomena suggested that microcirculation failure induced by traumarepairing process lead to occurence of osteoradionecrosis of jaws.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
1998年第1期5-7,T001,共4页
West China Journal of Stomatology
基金
上海市高教局基金
