摘要
目的 研究肝炎后肝硬化患者血清一氧化氮（ＮＯ）及一氧化氮合酶（ＮＯＳ）水平的变化。方法 实验组：肝硬化患者５８例；对照组：正常健康者４０例。血清学检测指标：ＮＯ、ＮＯＳ含量、血清丙氨酸氨基转移酶（ＡＬＴ）、血清胆红素（ＳＢ）、清蛋白（ＡＬＢ）及血浆凝血酶原活动度（ＰＴＡ）。结果 肝硬化Ｃｈｉｌｄ－Ｐｕｇｈ Ｃ级患者血清ＮＯ明显增高，与Ｃｈｉｌｄ－Ｐｕｇｈ Ａ级及正常对照组比较有显著性差异（Ｐ＜０．０５）；而血清ＮＯＳ降低，与正常对照组及Ｃｈｉｌｄ－Ｐｕｇｈ Ａ、Ｂ级比较均有显著性差别（Ｐ＜０．０５）。结论 血清ＮＯ水平随肝硬化Ｃｈｉｌｄ－Ｐｕｇｈ分级增加而增高，而血清ＮＯＳ却呈负增加现象。
Objective To study the change and correlation between serum nitric oxide (NO) and nitric oxide synthase (NOS) in patients with hepatic cirrhosis. Methods The experiment group consisted of 58 patients with hepatic cirrhosis and the control group 40 healthy people. Tests included NO, NOS, alanine transaminase (ALT), serum total bilirubin (SB), albumin (ALB), and serum pro- thrombin activity (PTA) determination. Results Serum NO in sera of liver cirrhosis patients in- creased with the decline of hepatic function especially in Child - Pugh C grade. There was significant difference between the experiment group and the control group (P < 0.05). However, compared with the control group the patients' serum NOS level decreased significantly as hepatic function was increasingly impaired (P < 0.05). Conclusion Hepatic function becomes graver, the higher serum NO level in the lower serum NOS level.
出处
《上海第二医科大学学报》
CSCD
2001年第3期248-250,共3页
Acta Universitatis Medicinalis Secondae Shanghai
