摘要
[目的]研究紫杉醇周剂量联合方案的疗效及毒副作用。[方法]国产紫杉醇 (紫素 )50mg/m2,第1、8、15天静脉滴注3小时 ,用紫素前12小时口服地塞米松4 5mg两次。消化道肿瘤 ,包括食管癌、胃癌、原发性肝癌联合顺铂30mg/m2 和5氟尿嘧啶300mg/m2 静脉滴注第1、8、15天 ,休息一周后重复 ;其它恶性肿瘤 ,如非小细胞肺癌、乳腺癌、腮腺癌、软组织肉瘤、卵巢癌联合顺铂30mg/m2静脉滴注第1、8、15天 ,休息一周后重复。所有病例28天为一周期 ,治疗2个周期后评价疗效。[结果]共入组晚期恶性肿瘤患者30例 ,CR病例3 3 %(1/30) ,总有效率为53 3%(16/30)。其中初治病例的有效率为54 5 %(6/11) ,复治病例的有效率为52 6 %(10/19)(P>0 05) ;胃癌、非小细胞肺癌、乳腺癌有效率分别为55 6 %(5/9)、62 5%(5/8)、80.0 %(4/5)。化疗后ECOG评分比化疗前改善 ,差异有显著性(P<0 001) ,毒副反应只有Ⅰ～Ⅱ级的骨髓抑制和轻度的神经毒性(Ⅰ度40 % ,Ⅱ度6 7 %) ,患者多能很好耐受。[结论]紫素采用周剂量的给药方式治疗晚期恶性肿瘤疗效肯定 ,比传统3～4周给药方案疗效提高、毒副反应轻微 ,值得临床推广 ,尤其对已使用过蒽环类药物化疗的晚期胃癌患者仍然有效 ,生活质量改善明显 ,需扩大病例进一步研究。
To study the efficacy and adverse effects of weekly dosage paclitaxel.Domestic paclitaxel 50mg/m2 iv drip for 3 hours on d1,d8,d15;dexamethasone 4 5mg bid 12 hours before using domestic paclitaxel.For alimentary canal tumor,including esophageal,gastric,primary liver carcinoma,plus cisplatin 30mg/m2 and 5 fluorouracil 300mg/m2 combination iv drip on d1,d8,d15.Other tumors,including non small cell lung,breast,parotid gland,ovarian cancer and soft tissue sarcoma,plus cisplatin 30mg/m2 combination iv drip on d1,d8,d15.The chemotherapy was repeated every 28 days and was evaluable for the response after two cycles.Thirty patients were evaluable for response,the overall response rate was 53 3%(CR3 3%).The response rate of initial treatment was 54 4%;the response rate of retreatment was 52 6%(P>0 05).The response rate of gastric,non small cell lung and breast cancer was 55 6%,62 5% and 80% respectively.The main side effects were bone marrow depression (Ⅰ°～Ⅱ°) and peripheral neuropathy (Ⅰ°,40%;Ⅱ°,6 7%).[Conclusions]Weekly domestic paclitaxel with cisplatin and/or 5 fluorouracil combination is effective and tolerable side effects in the treatment of advanced malignancy.It is better than standard regimen (paclitaxel 175 mg/m2 given over 3 hours q3wks).
出处
《肿瘤学杂志》
CAS
2001年第1期34-36,共3页
Journal of Chinese Oncology
关键词
肿瘤
紫杉醇
药物疗法
临床方案
方案评价
neoplasms
paclitaxel
drug therapy
chinical protocols
program evaluation
