摘要
对10例鼻咽癌(NPC)活检标本、10例NPC患者及17例正常对照者外周血培养细胞微核形成率(MNFR)的对照研究表明,NPC瘤细胞MNFR既高于患者又高于对照者外周血培养细胞MNFR(p<0.05.p<0.01),而患者外周血细胞MNFR也明显高于对照(p<0.01)。在6例NPC活检组织中发现明显的染色体数目及结构异常,此外在1例标本中观察的罕见的熟前着丝粒分离(PCS)现象。本研究提示,NPC瘤细胞MNFR与其染色体畸变关系密切;微核测定可作为实体瘤细胞遗传学检测的辅助手段。
Micronucleus Formation Rate(MNFR)of 10 cases of NPC tumor cell(NPC T.C.),10 cases of cultured peripheral blood lymphocyte of NPC patients(NPC C.P.B.L.)and 17 cases of that of controls were investigated.There was a great significant difference among these groups.MNFR of NPC T.C.was much higher than that of NPC C.P.B.L. (p>0.05)and controls(p>0.01)Also,MNFR of NPC C.P.B.L.higher than that of controls(p>0.01).Significant chromosomal numeral and structural abnormalities were found in 6 cases of NPC T.C.Besides,a rare chromosomal anomal,the premature centremere spreading(PCS),was also observed in one sample of NPC T.C.The outcomes suggested that there existed a positive correlation between MNFR and chromosomal abnormality in NPC.Micronucleus testing might probably be applied as a supplementary method to cy- togenetic study of solid tumors.
出处
《华西医学》
CAS
北大核心
1991年第1期104-107,共4页
West China Medical Journal
关键词
鼻咽肿瘤
活检组织
微核形成
Micronucleus formation rate
Chromosomal abnormality
Nasopharygneal carcinoma
Biopsied tissue
