摘要
目的 研究化疗对胃癌患者细胞免疫功能的影响及其临床意义。方法 对 38例Ⅳ期胃癌患者采用ELF方案进行常规化疗 ,测定其化疗前后患者外周静脉血中NK细胞活性和T淋巴细胞亚群比例 ,并分析比较其化疗疗效。结果 化疗前NK细胞活性为 2 4.78± 8.42 ,化疗后为 19.40± 6 .38,两者有显著性差异 (P <0 .0 5 ) ,但对T淋巴细胞亚群比例变化的影响不明显 ;NK细胞活性下调组化疗疗效显著下降。结论 化疗对NK细胞活性有明显下调作用 ,但对T淋巴细胞亚群的影响并不明显 ;
Objective To study the effect of chemotherapy on cellular immunological function in patients with gastric carcinoma and its clinical significance.Methods NK cell activities and T lymphocyte subsets were detected in 38 patients with advanced gastric carcinoma before and after chemotherapy.Results NK cell activity was 24.78±8.42 before chemotherapy and 19.40±6.38 after chemotherapy.However there′re no significant alterations for T lymphocyte subset.Furthermore,the therapeutic effect of chemotherapy was also decreased in patient whose NK cell activity was decreased.Conclusion Chemotherapy could downregulate NK cell activity and decreased NK cell activity is corelated with decreased therapeutic effect.
出处
《实用癌症杂志》
2001年第3期313-314,共2页
The Practical Journal of Cancer
