摘要
目的 针对重度颅脑外伤后血浆、脑脊液和脑区内源性阿片肽 ,特别是 β 内啡肽明显升高 ,应用金尔伦 (盐酸纳洛酮 )探讨对重症颅脑外伤的临床疗效。方法 选择GCS5～ 8分患者 30例每天应用金尔伦 4 8毫克 ,随机以 30例同等伤情未用金尔伦药物治疗病例为对照组。观察意识觉醒 ,血液流变学及临床征象。结果 觉醒天数缩短 ,外伤后脑血管痉挛发生率 ,血液粘滞度降低 ,致残率减少。结论 金尔伦对于内源性阿片肽引起的生理功能的应激性疾病起效快、作用可靠 ,其使用安全 ,治疗过程中未见有毒副作用。
Objective To assess clinical effects of Naloxone in treatment of severe craniocerebral trauma. Methods 60 patients (GCS 5 8) were randomly assigned into two groups. 30 patients had been treated on routine and other 30 patients had been treated with naxolone. The consciousness, hemorrheology and clinical features of the two groups were compared. Results 1. The time of awakening and conscious recovery in treatment group were shortener than that in control. 2. Naloxone treatment can diminish viscosity. Hemorheologic parameters of treatment group were tested (P<0 01). 3. Brain vasospasm incidence rate was low. In treatment group, TCD spectral form and blood flow speed approach normal. 4. The disability rate was cut down in treatment group. On CT scan we found that brain malacoma range and incidence rate of traumatic hydrocrania were diminished in most of patients in treatment group.Conclusions As a specificity opioid receptor antagonist, Naloxone is safe and effective for treatment of post injury pathophysiologic changes due to endogenous opioid peptides in stress. Moreover, no side effects and long dated complication was found.
出处
《中华神经外科杂志》
CSCD
北大核心
2001年第3期143-145,共3页
Chinese Journal of Neurosurgery
