摘要
目的总结白细胞介素Ⅰ(IL-2)/高聚金葡素(BM828)胸腹腔注射治疗恶性胸腹水疗效和毒副作用。方法对47例合并胸腹液的恶性肿瘤病人采用白介素Ⅰ50万单位/高聚金葡素3000单位同时一次胸腹腔注射,每周二次,每两周为一疗程。结果总有效率87.5%,其中完全缓解79%,部分缓解8.5%,好转8.5%,无效4%,少部分病人出现寒战、发热、局部疼痛,分别占16%、23%、4%,未见心肝肾功能损害。结论我们认为白细胞介素Ⅰ,高聚金葡素胸腹腔注射治疗恶性胸腹液疗效显著、安全、操作方便、毒副作用小,值得推广。
ve To evaluate the efficacy and toxicites of IL-2/MB828 for malignant hydrothorax and ascites. Methods Fourty-seven patients with malignant tumor combinging hydrothorax and ascites weretreated with injection of IL-2 (50 thousand units)and BM828(3 thousand units )in thoracic and abdominal cavity at the same time. The injection was given twice a week and recycled every two weeks. Results The overall response rate was 87. 5% including complete response 79%, partial response 8. 5% ,improvement 8. 5% and failure 4% . Among 47 cases, chill、 fever and partial pain were detected respectively in 16%、 23% and 4%. No cardiovascular、 renal and hepatic harm were observed. Conclusion Injection of IL-2 /MB828 for maligant hydrothorax and ascites is an effective and safe treatment which is convenient for operatiorr and low toxicties. The treatment is worth popularzing.
出处
《现代肿瘤医学》
CAS
1998年第1期26-27,34,共3页
Journal of Modern Oncology
关键词
白细胞素素Ⅱ
高聚金葡素
恶性胸腹液
胸腹腔注射
IL-2 BM828 Maligant hydrothorax and ascites injections in thoracic and abdominal cavity
