摘要
目的 探讨西拉普利治疗高血压的临床疗效和安全性。方法 采用随机对照的方法治疗 115例高血压患者。结果 服药 8周后西拉普利组总有效率 89.8% ,收缩压和舒张压分别由治疗前 15 3± 15mmHg ,10 4± 9mmHg降至治疗后 131± 11mmHg ,91± 8mmHg ;依那普利组总有效率为 91.1% ,收缩压和舒张压分别由治疗前 15 5± 12mmHg ,10 2± 10mmHg降至治疗后 139± 14mmHg ,90± 9mmHg ,二组比较无统计学意义。西拉普利治疗后使收缩和舒张负荷均有下降 ,与用药前有显著的差别 ;无严重的不良反应。结论 一平苏是一种安全和有效的治疗轻中度原发性高血压的药物。
Objective\ To study efficacy and safety of cilazapril in treating patients with essential hypertension.Method\ 115 patients with hypertension were divided randomly into two groups:59 were treated with cilazapril and 56 were treated with enalopril.All the patients were washed out for one week,then took 2.5 mg cilazapril or 10 mg enalapril once a day in each group respectively for 8 weeks.If blood pressure was not reduced 2 weeks later,hydrochlorothiazide was added. Result\ The effective rate of cilazapril and enalapril was 89.8% and 91.1% respectively.The SBP and DBP reduced from 153±15 mmHg and 104±9 mmHg to 131±11 mmHg and 91±8 mmHg respectively in cilazapril group,and from 155±12 mmHg and 102±10 mmHg to 139±14 mmHg and 90±9 mmHg respectively in enalapril group.There were no significant differences in two groups.\ No side effects were observed in two groups. Conclusion\ Cilazapril is an effective and safe agent in treatment of mild and moderate essential hypertesion.
出处
《高血压杂志》
CSCD
2001年第2期112-114,共3页
Chinese Journal of Hypertension
