摘要
为了制得崩解迅速 ,吸收良好的钙制剂 ,利用化学反应的方法制得粒径为 0 1～ 2 0 μm的碳酸钙 ,并对羧甲基淀粉钠、羧甲基纤维素钙、可压性淀粉和交联羧甲基纤维素钠四种崩解剂的性质进行考察 ,选择了崩解性能良好的羧甲基淀粉钠和交联羧甲基纤维素钠作为崩解剂 ,将其制成片剂。片剂崩解时间可达
In order to produce calcium tablets which can rapidly disintegrate in the oral cavity and reduce irritation,the calcium carbonate powders (size between 0 1～ 20 μm ) were prepared by a chemical reaction. Furthermore, the disintegration properties of sodium carboxyl methyl starch (CMS Na), calcium carboxyl methyl cellulose (ECG 505), pregelatinized starch (PCS), and croscarmellose sodium were investigated under different pressures, and in different ratios. The CMS Na and croscarmellose sodium were chosen as the disintegrant to make calcium tablets possess excellent disintegration property. The results showed that the disintegration time of the tablets could shorten by 45 seconds.
出处
《沈阳药科大学学报》
CAS
CSCD
2001年第3期177-180,共4页
Journal of Shenyang Pharmaceutical University
关键词
速崩
钙片
崩解剂
碳酸钙
rapid disintegration
calcium tablet
disintegrant
calcium carbonate
