摘要
目的 研究不同碘摄入量人群的临床甲减和亚临床甲减患病率。方法 选择盘山、彰武和黄骅 3个农村社区 (分别为低碘、适碘和高碘地区 ) ,在入户问卷调查的基础上行采样调查。共问卷调查 16 2 87人 ,采样 376 1人。所有采样调查对象接受体格检查、测定血清TSH、甲状腺过氧化物酶抗体 (TPOAb)、甲状腺球蛋白抗体 (TGAb)和甲状腺球蛋白 (TG)、测定尿碘浓度及进行甲状腺B超检查。TSH异常者测定FT4 、FT3 和TSH受体抗体 (TRAb)。结果 盘山、彰武和黄骅社区成人尿碘水平分别为 10 3.1μg/L、374.8μg/L和 6 14.6 μg/L。盘山、彰武和黄骅社区临床甲减患病率分别为 0 .2 7%、0 .95 %和 2 .0 5 % ;亚临床甲减的患病率分别为 0 .91%、2 .90 %和 5 .96 %。引起临床甲减的主要原因是自身免疫性甲状腺炎 ,亚临床甲减中三分之一患者甲状腺自身抗体阳性。
Objective To investigate the prevalence of overt and subclinical hypothyroidism in the areas with different iodine intakes. Methods A cross sectional epidemiologic study in 3 rural communities of Panshan (iodine deficient), Zhangwu (covered by iodinated salt from 1996) and Huanghua (iodine excessive) was performed. In these communities, 4343, 7714 and 4230 inhabitants were respectively questioned about thyroid disorders. Of them 1103, 1584 and 1074 were physically examined and sera were sampled. The measurements included TSH, thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) in the sera. The serum FT 4, FT 3 and TSH receptor antibody (TRAb) were determined for the subjects with abnormal TSH. Urinaryiodineconcentrationandthyroidultrasounic imaging were also examined. Results The median urinary iodine (MUI) was 103.1 μg/L in Panshan, 374.8 μg/L in Zhangwu and 614.6 μg/L in Huanghua. The prevalence of overt hypothyroidism was 0.27%, 0.95% and 2.05%in Panshan, Zhangwu and Huanghua, respectively. Overt hypothyroidism occured more frequently in the women over 45 years. The prevalence of subclinical hypothyroidism was 0.91%, 2.90% and 5.96% in Panshan, Zhangwu and Huanghua, respectively. The main cause of overt hypothyroidism was autoimmune thyroiditis; One third of the cases with subclinical hypothyroidism showed positive thyroid autoantibodies. Conclusion Higher prevalence of overt and subclinical hypothyroidism was found in the rural communities with higher iodine supply in a cross sectional epidemiologic study, suggesting a possible role of increasing or exessive iodine intake in hypothroidism.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2001年第2期71-74,共4页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目 !(3 9970 3 5 0 )
美国中华医学基金会项目 !(98- 688IITD)
