摘要
目的 检测维生素D受体（VDR）在白癜风皮损中的表达。方法 利用RT-PCR方法首次检测了14例寻常型进展期白癜风患者皮损 VDRmRNA表达水平，并与正常人皮肤做对照。结果 与正常人皮肤 VDR ｍRNA水平相比较，进展期白癜风患者皮损VDRmRNA水平明显降低（P＜０.05）。结论 进展期白癜风皮损 VDRmRNA水平下降，可能对白癜风的发病起一定的作用。
Objective To study the expression level of VDRmRNA in lesions of vitiligo. Methods The expression level of VDR mRNA in lesional skin in lesional skin from fourteen patientswithprogressive vitiligo was studied by RT-PCR method.Results Compared with VDR mRNA expression in normal skin,the expression level of VDRmRNA in lesional vitiligo skin was markedly decreased． Conclusion The results indicate that decrease of VDR m RNA expression in lesional skin might play a role in the pathogenesis of vitiligo.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2001年第4期217-219,共3页
The Chinese Journal of Dermatovenereology
