摘要
目的 探讨AT1基因与高血压性肾脏损害的关系 ,评价十余种候选危险因子对原发性高血压肾脏损害的危险。方法 随机选取上海地区汉族人种原发性高血压病例 96例 ,采集的所有病例均有详细病史资料 ,留取血样本 ,进行生化指标检测和基因型分析。结果 (1)血内生肌酐清除率和血肌酐与AT1A/C多态性呈显著相关 (P <0 .0 1) ,AC基因型肾功能明显差于AA基因型 ;(2 )在多因素Logistic回归分析中 ,年龄、糖尿病和A/C基因型是原发性高血压并发肾脏损害的三个独立危险因素。 (P <0 .0 1)。结论 结论AT1基因A/C多态性是内生肌酐清除率的独立影响因素 。
Objective The aim of study is to investigate the association between AT 1 A 1166 C polymorphism and renal damage with essential hypertension and to assess the prevalence of several risk factors of renal damage with hypertension.Methods 96 patients with essential hypertension in Han nationality Shanghai region were enrolled in the randomized study. A complete clinical history and blood samples were obtained for detecting their biochemical items and their genetype analysis. Results (1) Serum creatinine ( P <0.01) and creatinine clearance ( P <0.01) are associated with AT 1 A 1166 C polymorphism. (2) Age( P <0.01), diabetes mellitus ( P <0.01) and AT 1 A 1166 C polymorphism ( P <0.01) are independent risk factors in a multivariate logistic regression model.Conclusion AT 1 gene A 1166 C polymorphism is independent risk factor of creatinine clearance and is partly related to renal damage of essential hypertension.
出处
《同济大学学报（医学版）》
CAS
2001年第3期17-18,29,共3页
Journal of Tongji University(Medical Science)
