摘要
为探讨儿童结核病短程化疗中药物的毒副作用及儿童的耐受性,对61例结核病患儿采用治疗前后检查肝、肾功能,尿常规,脑干测听或听力测定,观察(6～9)个月。结果显示年龄在7个月以上小儿毒副作用发生率小于2％,治疗期间无严重毒副作用发生;7个月以下患儿7例儿童中5例出现ALT、AST改变。提示严格掌握多药联用剂量的情况下,一般患儿对短程化疗能很好耐受,年龄在7个月以下婴儿加用保肝治疗仍然能接受短程化疗。
In order to explore the drug-toxicity of short-term chemotherapy and the tolerance to these drugs in children with tuberculosis. Hepatic and renal function tests, urine routine and brain-stem audiotory evoked potential or audio-metry have been prospectively assessed prior to and during the therapy in an interval of 6-9 months in 61 cases with tuberculosis. The results obtained indicated that the incidence of toxic and adverse reaction due to chemotherapy was found to be as low as 2%. No toxic reaction appeared during chemotherapy in affected children at the age of greater than 7 months. Otherwise, as increase in ALT and AST levels could be found in 5/7 affected cases at the age of less than 7 months. Through this observation , it is then suggested that no toxic reaction of short-term chemotherapy could take place in children at the age of greater than 7 months if combined drug-dosages are well controlled t whileas, even in children at the age of less than 7 months, this chemotherapy is also acceptable when an additional management of liver protection is rationally adopted.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2001年第3期140-141,共2页
Journal of Clinical Pediatrics
关键词
儿童
结核病
短程化疗
药物毒性
children tuberculosis short-term chemotherapy drug-toxicity
