摘要
目的 :比较两种阿昔洛韦片生物利用度和药代动力学。方法 :测定 10名受试者单剂量交叉口服6 0 0mg阿昔洛韦受试片和参比片后血药浓度 ,计算相应的药代动力学参数。结果 :受试者口服两种阿昔洛韦片计算的峰浓度Cmax、Tmax和AUC分别为Cmax1.2 4± 0 .49和 1.17± 0 .2 0 μg/ml,Tmax1.9± 0 .6h和 2 .1± 1.1h ,AUC7.5 6± 1 80和 7.5 6± 2 .10 μg·h/ml。相对生物利用度 10 1.36 %± 11.6 2 %。双单侧t检验显示两制剂的Cmax和AUC无显著性差异。结论
AIM to compare the bioavailability and pharmacokinetics of two acyclovir tablets. METHODS Concentrations of acyclovir in 10 men serum after po 600 mg of two acyclovir tablets were determined , in random 2 way crossover design. Pharmacokinetic parameters were also estimated. RESULTS The peak concentrations of test and reference tablets were 1.24±0.49 and 1.17±0.20 μg/ml, the AUC 7.56±1.80 and 7.56±2.10 μg·h/ml, respectively. The relative bioavailability was 101.36%±11.62%. The test formulation was found bioequivalent to the reference in AUC and C max by two one side t test. CONCLUSION\ Two tablets were bioequivalent.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2001年第3期210-212,共3页
Journal of China Pharmaceutical University
