摘要
目的 :筛选盐酸去氢骆驼蓬碱软膏的处方组成。方法 :采用正交试验设计 ,以软膏中有效成分盐酸去氢骆驼蓬碱的透皮吸收速度常数K和流动活化能Eη 为考察指标。结果 :得到最佳基质处方为 :氮酮 (2 .0 % )、司盘 80 (0 .2 % )、吐温 80 (0 .4% )、单硬脂酸甘油酯 (2 .5 % )、凡士林 (4 .0 % )、液体石蜡 (11% )。结论 :该软膏处方设计合理、制剂稳定性好。
Objective: To select the prescription of Harmine HCl ointment. Methods: The orthogonal design was used for selecting the prescription with transdermal absorption rate constant (K) and flow energy of activition (E η) as selecting standard. Results: The optimum prescription is as follows: Azone (2.0%), Span-80 ( 0.2%), Tweens-80 (0.4%), Glycerylmonostearate (2.5%), Vaselin (4.0%), Liquid (11%). Conclusion: The prescription design is available, and the ointment has a good stability.
出处
《中成药》
CAS
CSCD
北大核心
2001年第5期316-318,共3页
Chinese Traditional Patent Medicine
关键词
盐酸去氢骆驼蓬碱
软膏
处方
正交试验
透皮吸收
流变学
Harmine HCl
ointment
prescription
orthogonal design
transdermal absorption
rheoligy
