摘要
目的 比较体外培养的瘤细胞对重离子和γ射线的辐射敏感性。方法 以人肝癌SMMC 772 1、宫颈癌HeLa和小鼠黑色素瘤B16细胞为材料 ,用集落形成法研究了细胞经γ射线和重离子处理后的存活情况。结果 细胞经γ射线处理后均表现为有肩区的存活曲线 ,属多靶击中模型。细胞经重离子处理后表现为无肩区的存活曲线 ,属单靶击中模型 ,在细胞存活分数为 5 0 %和 10 %时得到SMMC 772 1、HeLa、B16细胞的RBE值分别为 3 40、2 76、4 6 7和 1 88、1 5 3、2 2 2。结论 在相同剂量下 。
Objective To compare the radio-sensitivity of various tumo r cells irradiated with heavy ions and γ-rays.Methods The cell lines for test were human hepatoma SMMC-7721,HeLa and melanoma B16 cells, afte r treated with γ-rays and heavy ion, the survivors were studied by colony-for mation assays.Results The survival curves of γ-rays had shoul ders and showed as multi-target models; The survival curves of heavy ions showe d as lines and one-target models, when survival fractions were 50% and 10%, the RBE of SMMC-7721,HeLa and B16 cells were 3.40?2.76?4 67 and 1.88?1 53?2 22,respectively. Conclusion Under the same dose, heavy ions could kill the tumor cells more efficiently
出处
《肿瘤》
CAS
CSCD
北大核心
2001年第4期249-250,共2页
Tumor
基金
中科院院长特别基金资助项目 (编号 :TB990 60 1)
