摘要
目的 探讨脑白质疏松症 ( L A)患者认知功能和血浆生长抑素 ( SS)含量的关系。方法 研究对象分为 L A痴呆组 2 6例 ,L A非痴呆组 4 7例和正常对照组 3 8例。 3组均接受长谷川痴呆量表 ( HDS)评定及血浆 SS含量的检测。结果 与对照组比较 ,L A患者 (包括痴呆组和非痴呆组 ) HDS评分和血浆 SS含量均明显下降 (均 P<0 .0 0 1) ;L A痴呆组与 L A非痴呆组比较 ,HDS评分也明显下降 ( P<0 .0 0 1) ;血浆 SS含量虽有下降 ,但没有显著差异 ( P>0 .0 5 )。结论 L A可影响认知功能 ,在患者尚未发生痴呆之前 ,血浆 SS含量就已下降 ,推测 L A患者认知功能障碍可能与体内
Objective To explore the relationship between the cognitive function and plasma somatostatin(SS) level in the patients with leukoaraiosis(LA).Methods According to the clinical findings and CT imaging,the subjects were divided into three groups:26 patients with LA and dementia, 47 patients with LA but without dementia, and the normal controls for 38 cases. The three groups were determined by means of Hasegawa's Dementia Scale(HDS)and SS levels in plasma.Results As compared with the control group,HDS score and plasma SS level in patients with LA (including dementia group and non dementia group) decreased remarkable(P< 0.001 ).Compared with patients with LA and non dementia,HDS score decreased significantly in patients with LA and dementia( P <0.001); although the levels of plasma SS decreased,there was no significantly difference ( P >0.05).Conclusion LA might be the cause of cognitive impairment,the concentrations of plasma SS had declined before dementia did not occur,the cognitive impairment in patients with LA might relate to the decrease of SS levels in the body.
出处
《临床神经病学杂志》
CAS
2001年第4期206-208,共3页
Journal of Clinical Neurology
关键词
脑白质疏松
认知功能
生长抑素
Leukoaraiosis Cognitive function Somatostatin
