摘要
应用 3因素 3水平的正交试验法 ,研究β-环糊精对异维 A酸的包合作用 ,选择包合物的包合率为考察指标 ,优化出异维 A酸 - β-环糊精包合物的最佳工艺条件 ,包合率为 98.6% ,采用 3种不同的包合方法制备异维 A酸 - β-环糊精包合物 。
In this study 3 factors and 3 levels of condition for the preparation of isotretinoin β cyclodextrin inclusion compound were selected by orthogonal design. The inclusion rate was used as the criteria of selecting the optimal condition. According to the optimal condition the inclusion compound was prepared by 3 methods. The results showed that the grinding method was the best and the inclusion rate was 98 6%.
出处
《西北药学杂志》
CAS
2001年第4期168-169,共2页
Northwest Pharmaceutical Journal
关键词
异维A维
Β-环糊精
包合物
正交试验
isotretinoin
β cyclodextrin
inclusion compound
orthogonal design
