摘要
目的 初步探讨湿化剂改善肺水肿氧疗效果的作用机理。方法 复制急性肺水肿动物模型 ,并分组给予不同浓度的乙醇湿化给氧 ,观察吸氧前后PaO2 和BALF中SOD和磷脂含量、血浆NO以及肺系数的变化。结果 各组PaO2 在吸氧后均明显增高 (P <0 .0 1) ,尤以 15 %、2 5 %乙醇氧组增高显著 ;15 %、2 5 %乙醇氧组BALF中SOD的含量明显高于 5 0 %乙醇氧组 (P <0 .0 5 ) ,15 %乙醇氧组BALF中磷脂含量明显高于其他各组 (P <0 .0 5 ) ;浓度越高的乙醇对水肿液的消泡作用越强 ,但同时有较多的蛋白絮状沉淀物形成。结论 15 %乙醇为最佳浓度湿化剂 ;湿化剂对肺水肿氧疗效果的影响除与其消泡作用有关外 。
Objective\ To explore the mechanism about the effect of humidifying agent when pulmonary inhaling oxygen .Method\ 18 pulmonary rabbits divided into 3 groups at random ,given oxygen inhalation with different concentration alcohol as humidifying agent. Results\ The blood PaO 2 improved obviously at the groups of 15% and 25% alcohol oxygen (P<0.01);the SOD content inside BALF are higher at the groups of 15% and 25% alcohol oxygen (P<0.05),and the phospholipid content inside BALF at 15% alcohol oxygen group is higher(P<0.05);different concentration alcohol has different suppressing foam effect, the higher the alcohol concentration, the more the effect; at meanwhile ,the protein sediment formed ,the higher the alcohol concentration, the more sediment. Conclusion\ 15% alcohol as humidifying agent has the best effect ;the effect of humidifying agent on pulmonary is influenced not only by the suppressing foam effect ,but also by the nature of the material itself forming foam and oxygen free radical and others.
出处
《实用护理杂志》
北大核心
2001年第9期1-2,20,共3页
Journal of Practical Nursing
基金
山东省卫生厅自然科学基金资助
关键词
湿化剂
肺水肿
吸氧疗效
实验研究
humidifying agent
pulmonary
effect for oxygen therapy
mechanism
