摘要
对 30例正常人 (正常对照组 )及 6 0例原发性高血压 (EH)患者 (EH组 ,其中轻度 EH33例、中度 2 7例 )进行用药前后尿α1 -微球蛋白 (α1 - MG) ,β2 -微球蛋白 (β2 - MG) ,转铁蛋白测定。结果发现 :轻度 EH组β2 - MG、α1 -MG明显高于对照组 (P <0 .0 1) ;中度 EH组 β2 - MG、α1 - MG、转铁蛋白明显高于轻度 EH组和对照组 (P <0 .0 1,P <0 .0 0 1) ;应用氨氯地平治疗后 ,EH组尿 β2 - MG、α1 - MG、转铁蛋白均较治疗前明显降低 (P <0 .0 1,P<0 .0 0 1)。认为尿 β2 - MG、α1 - MG、转铁蛋白检测能较早识别高血压肾脏损害 ,氨氯地平在降压的同时预防或延缓肾脏损害的发生发展。
To study the changes of microglobin and transferrin in essential hypertensive patients and the effect of amlodipine therapy,the concentration of urinary β 2 MG,α 1 MG and transferrin in 60 essential hypertensive patients and 30 normal persons were measured before and after amlodipine treatment The result showed that the concentration of urinary β 2 MG,α 1 MG and transferrin in mild and moderate EH group were significantly higher than that in the control group(P<0 01)and were significantly lower after amlodipine treatment than that before treatment (P<0 01,P<0 001) This suggestS that cletation of urinary β 2 MG,α 1 MG and transferrin may identify hypertensive kidney injury earlier Amlodipine can protect and prevent the occurence and Progression of kidney injury besides its antihypertensive effect
出处
《山东医药》
CAS
北大核心
2001年第10期8-9,共2页
Shandong Medical Journal
