摘要
目的 对患者进行血小板抗原基因分型及配型的研究 ,以探讨临床血小板输注的安全、有效性。方法 应用聚合酶链 序列特异性引物技术 (PCR SSP) ,对南京地区 5 5例患者HPA1 5系统等位基因进行分型 ,并为其进行血小板基因配型输注。结果 经血小板基因配型的吻合组血小板输注效果明显优于未经配型的对照组。结论 对患者进行血小板抗原基因分型及配型可提高血小板输注的安全、有效性。
Objective\ Genotyping and matching of human platelet antigen(HPA)were studied in patients,to ensure safety and effectiveness of platelet transfusion Methods \ PCR SSP method for HPA genotyping was developed Genotypes of HPA 1 to 5 in 55 patients were determined by the PCR SSP method Matching of HPA genotypes in 55 patients was done before platelet transfusion Results\ The effectiveness of platelet transfusion in the group of platelet genotypes matched is superior to the no matched group′s Conclusion\ Genotyping and matching of HPA for patients can ensure safety and effectiveness of platelet transfusion
出处
《临床检验杂志》
CAS
CSCD
北大核心
2001年第4期207-209,共3页
Chinese Journal of Clinical Laboratory Science
关键词
人血小板抗原
基因分型
配型
血小板输注
Human platelet antigen(HPA)
Genotyping
Matching
Platelet transfusion
