摘要
目的 对 4例肺癌肉瘤回顾性临床病理研究 ,探讨肺癌肉瘤的临床病理特点。方法 采用组织病理学、免疫组织化学 (ker atin、Desmin、Actin、S -10 0蛋白、Myoglobin)对 4例肺癌肉瘤进行研究并文献复习。结果 肺癌肉瘤多见于 5 0岁以上男性 ,临床多表现为咳嗽、咯血或胸痛 ,光镜及免疫组织化学标记提示肺癌肉瘤多以鳞癌、腺癌等恶性上皮成份为主 ,伴多少不等的异源性恶性间叶成份 ,如横纹肌肉瘤、软骨肉瘤、骨肉瘤。本病预后较差。结论 肺癌肉瘤临床上与肺癌不易区别 ,明确该肿瘤的组织起源及病理特征 ,对于诊断及鉴别诊断有重要意义。
Objective By means of retrospective study on 4 cases of lung carcinosarcoma(LCS),analyze their clinical manifestations and histopathological features.Methods Histopathological and immunohistochemical staining for Keratin,Desmin,Actin,S-100 protein and Myogloblin was studied.Results The lung carcinosarcoma often occurred in males above 45 years old.Cough,hemoptysis and chest pain were their initial symptons.Using light microscopy and immunohistochemical staining,the most frequent epithelial component was squamous cell carcinoma,followed by adenocarcinoma,including heterologous elements such as malignant cartilage,bone or skeletal muscle.Conclusions The lung carcinosarcoma is easily confused with lung carcinoma in clinical features.The pathogenesis and histopathology are important for diagnosis and differential diagnosis.
出处
《河南肿瘤学杂志》
2001年第4期237-239,共3页
Henan Journal of Oncology
关键词
癌肉瘤
组织起源
组织病理学
免疫组织化学
肺癌
lung tumor
carcinosarcoma
pathogenesis
immunohistochemistry
histopathology
