摘要
目的 研究乙型肝炎的远期免疫效果。方法 采用单纯随机方法连续 13年对 1986年出生并接种乙型肝炎疫苗的儿童进行隔年随访 ,采血检测HBsAg、抗 HBs、抗 HBc。结果 13年间HBsAg阳性率在 0 46 %～ 0 97%之间 ,未随免疫时间的延长而上升 ,乙型肝炎疫苗的远期保护效果为81 67% ,与近期免疫效果相当。结论 免疫后
Objective To evaluate long term efficacy of hepatitis B vaccination in newborns.Methods In the past 13 years we followed up the children who had been immunized with hepatitis B vaccine at birth in 1986 every other year. At each follow up visit, every child was tested for HBsAg, anti HBs and anti HBc.Results HBsAg positive rate of these birth cohort was low (range between 0 46% and 0 98%) during 13 years' follow up. Long term efficacy of the vaccination in preventing HBsAg carriage was confirmed.Conclusion Thirteen years later no booster was after needed.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
北大核心
2001年第3期239-241,共3页
Chinese Journal of Experimental and Clinical Virology
关键词
病毒性肝炎疫苗
乙型肝炎表面抗原
新生儿
免疫
Viral hepatitis vaccines
Hepatitis B,surface antigens
Long term efficacy
