摘要
目的 :通过对急性肺水肿不同湿化剂吸氧疗效的动物实验 ,筛选一种合适的湿化剂。方法 :复制急性肺水肿的动物模型 ,给予蒸馏水及不同浓度的乙醇、丁醇湿化吸氧 ,观察吸氧前后PaO2 变化及支气管肺泡灌注液 (BALF)中SOD及血浆NO变化情况。结果 :各组PaO2 在吸氧后明显增高 ,尤以 15 %、2 5 %乙醇组增高显著 (P均 <0 0 1) ,肺系数显著低于未吸氧组 (P <0 0 1) ;15 %乙醇组BALF中SOD显著高于其它各组 (P <0 0 5 ) ,血浆NO在吸氧后亦明显升高 ,但与其它各组无显著性差异。结论 :①低浓度乙醇 (15 %～ 2 5 % )为最佳湿化剂浓度 ,丁醇不适合作湿化剂 ;②不同湿化剂对肺水肿吸氧疗效的影响除与其消泡作用有关外 ,尚与水肿液成份及其它因素有关。
Objective:To study the effect of different humidifying agent on oxygen inhalation in acute pneumonedema of rabbits and select the suitable humidifying agent.Methods:Rabbit models with acute pneumonedema were made by rapid transfusing,and given oxygen inhalation with 15%,25%,50% alcohol,7.5% buty1 alcohol and distilled water as humidifying agent.The changes of PaO 2 SOD in BALF and NO in serum after oxygen inhalation were observed.Results:PaO 2 in 15% and 25% alcohol oxygen group increased more significantly than in other groups ( P<0 05) ,but there was no significant difference between the two group.In 15% alcolol oxygen group,SOD in BALE was higher than that in 25% group and NO in serum was higher than others,but there was no significant difference between these groups.Conclusion:①Low degree alcohol(15%～25%) is the best humidifying agent,buty1 alcohol is not suitable.②The role of humidifying agent is affected not only by its depressing foam but also the component in edema fluids.
出处
《山东医科大学学报》
2001年第4期332-333,337,共3页
Acta Academiae Medicinae Shandong
基金
山东省卫生厅资助课题 ( 9747)
关键词
急性肺水肿
湿化剂
吸氧
疗效
实验研究
Pulmonary edema
Water
Alcohol,ethy1
Alchols,butyl
Oxygen
Rabbits
