亚细胞的Ca^(2+)动力学
Subcellular Ca^(2+) dynamics
摘要
阐述了内质网、线粒体、细胞核及其他亚细胞区域的Ca2 + 浓度在细胞静息及活化状态下的变化及其可能的机制。
The changes and mechanisms of intracellular Ca 2+ concentration in endoplasmic reticulum, mitochondria, nu cleoplasma and so on are presented in this review.
基金
国家自然科学基金 ( 39930 0 80 )资助项目
参考文献16
-
1Oancea E, meyer T. Reversible desensitization of inositol trisphosphate-induced calcium release provides a mechanismfor repetitive calcium spikes[J]. J Biol Chem, 1996, 271:17 253-17 260.
-
2Babcock DF, Hille B. mitochondrial oversight of cellular Ca2 + signalling[J]. Curr Opin Neurobiol, 1998, 8:398-404.
-
3Berridge MJ. Elementary and global aspects of calcium signalling[J]. J Physiol, 1997, 499:291-306.
-
4Neher E. Vesicle pools and Ca2 + microdomains: new tools for understanding their roles in neurotransmitter release [ J ]. Neuron,1998, 20: 389-399.
-
5Pozzan T, Rizzuto R, Volpe P, et al. Molecular and cellular physiology of intercellular calcium stores[ J]. Physiol Rev, 1994,74:595 -636.
-
6Meldolesi J, Pozzan T. The endoplasmic reticulum Ca2+ store: a view from the lumen[ J]. Trends Biochem Sci, 1998,23:10-14.
-
7Alonso MT, BarreroMJ, CarniceroE, et al. Functional measuremements of [ Ca2 + ] in the endoplasmic reticulum using a herpes virus to deliver targeted aequorin [ J ]. Cell Calcium, 1998, 24:87 -96.
-
8Berrero M J, Montero M, Alvarez J. Dynamics of [ Ca2+ ] in the endoplasmic reticulum and cytoplasm of intact Hela cells[ J]. J Biol Chem, 1997,272:27 694-27 699.
-
9Miyawaki A, Llopis J, Heim R, et al. Fluorescent indicators for Ca2 + based on green fluorescent proteins and calmodulin[ J ]. Nature, 1997,388:882-887.
-
10Mogami H, Tepikin AV, Petersen OH. Termination of cytosolic Ca2+ signals: Ca2+ reuptake into intracellular store lumen [ J ]. EMBO J, 1998,17:435-442.