摘要
目的 探讨粘附分子CD44v6和E cadherin表达与甲状腺乳头状癌 (PTC)侵袭转移的关系。方法 应用S P免疫组织化学方法检测 58例甲状腺乳头状癌组织中CD44v6和E cadherin的表达。结果 甲状腺乳头状癌组织中CD44v6和E cadherin表达阳性率分别为 72 .4%和 41 .4% ;CD44v6表达阳性率与PTC的侵袭和转移呈正相关 (P<0 .0 5) ,而E cadherin表达阳性率与PTC的侵袭和转移呈负相关 (P<0 .0 1 ) ,且两种粘附分子在PTC中的阳性表达呈负相关性 (P<0 .0 5)。结论 粘附分子表达与PTC侵袭和转移密切相关 ,检测CD44v6和E cadherin的表达可作为判断甲状腺乳头状癌预后的参考指标。
Objective To investigate the correlation of adhesive molecule expressions with potential of invasion and metastasis in papillary thyroid carcinoma (PTC). Methods S P immunohistochemical method was used to detect CD44v6 and E cadherin expression in 58 cases of PTC. Results The positive rates of CD44v6 and E cadherin in PTC were 72.40% and 41.4% respectively. There was a positive correlation between CD44v6 expression and tumor invasive and metastatic potential in PTC ( P <0.05), and a reverse correlation between E cadherin expression and the potential ( P < 0.01). Moreover,there was a reverse correlation between the CD44v6 and E cadherin expression in PTC( P <0.05). Conclusion These data show a correlation between the adhesive molecule expression and the potential of invasion and metastasis in PTC. CD44v6 and E cadherin may be prognostic indicators in PTC.
出处
《中国普外基础与临床杂志》
CAS
2001年第5期317-318,共2页
Chinese Journal of Bases and Clinics In General Surgery
