摘要
目的 :研究放疗前加化疗对中晚期食道癌的疗效观察。方法 :64例中晚期食道癌随机分为两组 ,单放组 32例 ,为单纯体外放疗 ,剂量 60～ 70Gy/ 6～ 7周 ,综合组 32例 ,按上述放疗外 ,在放疗前行 2程诱导化疗 (CF +5Fu +DDP)。结果 :综合组与单放组 1、2、3年生存率分别为 65 .9%、46.9%、31.3%和 40 .6%、31.3%、12 .5 % ,综合组生存率明显高于单放组 (P <0 .0 5 ) ,且无严重毒副作用。综合组与单放组局控率分别是 5 6.3%和 62 .5 % ,两组差异无显著性 (P >0 .0 5 ) ,但远处转移率综合组为 6.3% ,单放组为 18.8% ,综合组明显低于单放组 (P <0 .0 5 )。结论 :放疗治疗中晚期食道癌前行化疗是疗效好 。
Objective:The effect on efficacy of pre irradiation chemotherapy for advanced esophageal carcinoma was investigated.Methods:64 patients with advanced esophageal cancer were divided randomly into group 1(R),and group 2(R+C).In R group 32 patients received radiotherapy alone.In (R+C) group 32 patients received additional pre irradiation chcmotherapy(CF+5 FU+DDP).Results:The one,two and three year survival rates were 65.9%,46.9%,31.3% in R+C group and 40.6%,31.3%,12.5% in R group,respectively,The survival rates in R+C group were much higher than those in R group (P<0.05),The local control rates,56.3% in R+C group and 62.5% in R group,had no differences(P>0.05),but there was significant differences in distant metastasis between two groups,6.3% in R+C group and 18.8% in R group,R+C group was much lower than R group (P<0.05).Conclusion:Chemotherapy with CF?5 Fu and DDP before radiotherapy for esophageal carcinoma had good effect and were worth further studying in clinic.
出处
《右江医学》
2001年第4期282-283,共2页
Chinese Youjiang Medical Journal
关键词
放射治疗
化疗治疗
食管癌
esophageal neoplusms
radiotherapy
themotherapy
