摘要
目的 :检测妊娠期肝内胆汁淤积症 (ICP)患者血清及新生儿脐血中可溶性细胞间粘附分子 - 1(SICAM - 1)及其临床意义。方法 :采用酶联免疫吸附法 (ELISA)检测各项指标。结果 :(1)ICP患者血清、新生儿脐血中SICAM - 1的浓度明显高于正常孕妇组 (P<0 .0 1) ,随着ICP程度的增加 ,SICAM - 1的浓度逐渐增高 (P <0 .0 5 ) ;两组孕妇产后 1周母血中SICAM - 1逐渐降至正常 (P >0 .0 5 ) ;(2 )ICP患者血清中SICAM - 1的升高与胆汁酸 (BA)、ALT、AST呈正相关 (P <0 .0 0 1,P <0 .0 0 5 )。结论 :ICP患者血清、新生儿脐血中SICAM -
Objective:To detect the serum of soluble intercellular adhesion molecule-1 (SICAM-1) in patients with intrahepatic cholestasis of pregnancy (ICP) and neonate's cord blood and their clinical significance.Methods:Each index was detected by ELISA.Results:(1)The concentration of SICAM in the serum of patients with ICP and neonate's cord blood was higher than that in normal pregnancy group significantly (P<0.01).The concentration of SICAM-1 became higher with the severity of ICP(P<0.05).The level of SICAM-1 in pregnancies of two groups decreased gradully one week after delivery.(2) The level of SICAM-1 from women with ICP had a significant positive correlation with bile acid (BA),ALT and AST (P<0.001,P<0.01,P<0.05,respectively). Conclusions:There is an important role of elevated maternal serum and neonate's cord blood levels of SICAM-1 in genesis of patients with ICP.
出处
《现代妇产科进展》
CSCD
2001年第4期276-278,共3页
Progress in Obstetrics and Gynecology
关键词
胆汁郁积症
肝内
妊娠
并发症
脐血
细胞粘着分子
Cholestasis,intrahepatic
Pregnancy complication
Cord blood
Cell adhesion molecules
