摘要
以对氯苄腈为起始原料 ,经环烃化、Grignard反应、还原、Eschweiler -Clarke甲基化反应以及成盐等合成了盐酸西布曲明 ,总收率 4 1.9% ,优化和改进了反应条件。产物经熔点、红外、元素分析、1
Sibutramine hydrochloride was synthesized from 4-chlorophenylacetonitrile by reactions of cycloalkylation, Grignard reaction, reduction, Eschweiler-Clarke methylation and salifying in 41.9% overall yield. The synthetic conditions of reaction were improved and optimized. The product was characterized by mp, IR, elemental analysis and 1HNMR.
出处
《安徽大学学报（自然科学版）》
CAS
2001年第3期82-86,共5页
Journal of Anhui University(Natural Science Edition)
