摘要
目的 :探讨 PTEN/ MMAC1/ TEP1与大肠癌的发生 ,发展的相关性。方法 :应用 S- P免疫组织化学方法检测 2 3例正常大肠粘膜、 2 8例大肠腺瘤和 75例大肠癌组织中 PTEN/ MMAC1/ TEP1蛋白的表达情况。结果 :2 3例正常大肠粘膜组织中PTEN蛋白表达阳性率为 91.3% (2 1/ 2 3) ,2 8例大肠腺瘤组织中 PTEN蛋白表达阳性率均为 89.3% (2 5 / 2 8) ,75例大肠癌组织中 PTEN蛋白表达阳性率为 6 8% (5 1/ 75 ) ,与正常大肠粘膜及大肠腺瘤差异有显著意义 (P <0 .0 1) ;有淋巴结转移的2 8例大肠癌阳性率为 43% (12 / 2 8) ,无淋巴结转移的 47例大肠癌阳性率为 83% (39/ 47) ,两者差异有显著意义 (P <0 .0 1) ;有远处器官转移的 2 3例大肠癌中阳性率为 43.5 % (10 / 2 3) ,无远处器官转移的 5 2例大肠癌阳性率为 78.8% (4 1/ 5 2 ) ,差异有显著意义 (P〈0 .0 1) ;6 0例大肠腺癌中蛋白表达阳性率为 81.2 % (4 9/ 6 0 ) ,15例粘液癌蛋白表达阳性率为 13.3% (2 / 15 ) ;两者之间有显著性差异 (P <0 .0 1) ;6 0例大肠腺癌中高 /中分化大肠腺癌 37例表达阳性率为 97.3% (36 / 37) ,低分化大肠腺癌 2 3例中表达阳性率为 5 6 .5 % (13/ 2 3) ,两者差异有显著意义 (P <0 .0 1)。结论 :PTEN/ MMAC1/ TEP1与大肠癌的发生。
Objective: To evaluate the relationship between PTEN/MMAC1/TEP1 expression and colorectal adenoma and carcinoma Methods:23 cases of human normal large intestinal mucosa,28 cases of colorectal adnoma and 75 cases colorectal carcinoma were investigated by immunohistochemical S P techinque through applieation of PTEN/MMAC1/TEP1 antibody Results:In the cases of nomal large intestinal mucosa and colorectal adnoma and carcinoma,the PTEN positive expression rates were 91 3%(21/23) and 89 3%(25/28) and 68%(52/75) respectively,and the differences were significant,P<0 01 The positive rates of those with or without lymph node metastasis were 43%(12/28) and 83%(39/47),and the differences were significiant,P<0 01 The positive rates of those with or without metastasis of distant organswere 43 5%(10/23) and 78 8%(41/52),P<0 01 The positive rates of colorectal adenocarcinoma and mucinous adenocarcina were 81 2%(49/60) and 13 3%(2/15),P<0 01;In the 60 cases of colorectal adenocarcinoma,the positive rates of well or moderately differentiated type and poorly differentiated type were 97 3%(36/37)and 56 5%(13/23),P<0 01 Conclusion:The results suggest that PTEN shows inhibitory effect on the occurence those and development ofcolorectalcarcinoma It may be of great value for clinical prognosis
出处
《大肠肛门病外科杂志》
2001年第2期9-13,共5页
Journal of Coloproctological Surgery
