摘要
目的 研究子宫腺肌症生物学行为与外周血雌、孕激素及其受体、肌层病灶内血流指数的关系。方法 收集经手术病理证实的子宫腺肌症患者 10 8例临床资料 ,用免疫组化法及放射免疫法测定 42例患者外周血雌、孕激素及组织病灶内雌激素受体 ,用彩色多普拉超声检测 86例患者肌层病灶内血流指数。结果 重度痛经组平均雌二醇 96 0 pmol/L ,雌激素受体≥ ++的比例为 88.4% ,显著高于轻度痛经组 (P <0 .0 5 ) ;重度痛经组平均搏动指数 (PI)值 1.40 ,显著高于轻度痛经组 1.13(P <0 .0 5 ) ;月经过多组合并内膜增生过长率及子宫≥ 6孕周者 91.7% ,显著高于月经正常组 (P <0 .0 5 )。结论 子宫腺肌症生物学行为与雌孕激素及其受体。
Objective To investigate the relationship among the biological activity in patients with uterine adenomyosis and these blood level of E, P, ER, PR as well as the blood flow index in the myometrial lesions. Methods One hundred and eight patients women (pathologically confirmed after operation) were included in this study. The levels of E, P, ER, PR of forty two women were assessed with immunohistochemical and radioimmunity methods, and the blood flow index in the myometrial lesions of eighty six patients was measured by color Doppler ultrasonography. Results The mean E level was 960 pmol/L in severe dysmenorrhea group, with a ratio of ER≥(++) being 88.4%, and the mean PI being 1.40, all were significantly higher than those of the mild dysmenorrhea group. The incidence of endometrial hyperplasia and uterine size beyond six gestational weeks in the menorrhagia group was 91.7%, significantly higher than the normal menstruation group( P <0.05).Conclusion The biological activity of adenomyosis is related to the E, P, ER, PR levels, PI in myometrial lesion and endometrial hyperplasia.
出处
《上海医学》
CAS
CSCD
北大核心
2001年第6期346-347,共2页
Shanghai Medical Journal
关键词
子宫腺肌症
血流指数
生物学行为
Adenomyosis
Index of blood flow
Biologic behavior
