摘要
目的 探讨介入化疗在阴道原发性恶性肿瘤综合治疗中的作用。方法 采用Seldinger方法 ,对 14例中晚期阴道原发性恶性肿瘤患者施行双侧髂内动脉插管介入化疗 ,上皮性肿瘤和肉瘤灌注顺铂 (DDP) 80mg、表阿霉素 (E ADM)70mg ,黑色素瘤加用氮烯咪胺 (DTIC) 80 0mg。间隔 2周重复 ,每例患者化疗 2～ 4次。介入治疗前及介入治疗后 10～14天行妇科检查 ,辅以B超或CT检查 ,以评定治疗效果 ,根据病灶消退情况选择进一步的手术或放射治疗。结果 介入化疗后CR 2例 ,PR 9例 ,3例肿瘤缩小在 5 0 %以下 ,有效率 (CR +PR)为 78 6 %。介入化疗后 ,5例行手术治疗 ,肿瘤完全切除 ,切缘未见肿瘤残留 ;7例行补充放疗 ,除 1例介入治疗后无效行放疗有肿瘤残留外 ,其余 6例放疗后肿瘤残留 ;7例行补充放疗 ,除 1例介入治疗后无效行放疗有肿瘤残留外 ,其余 6例放疗后肿瘤完全消退。结论 介入插管化疗对中晚期阴道恶性肿瘤 ,近期疗效明显 ,毒副反应轻 ,为手术或放疗创造了条件 ,是一种可行的有效的治疗方法。
Objective To evaluate the clinical effect of intraarterial chemotherapy of primary vaginal carcinoma. Methods In 14 patients of primary vaginal carcinoma, Intraarterial chemotherapy with cisplatin 80 mg, epirubincin 70 mg. and dacarbazine 800 mg,(only for melanoma) were used once evey 2 weeks,for 2～4 cycles. Patients' response were evaluated with clinical and ultrasogram or CT examination. According to the different chemotherapy results. patients were followed by surgery or radiotherapy. Results The results of intraarterial chemotherapy:2 patients showed complete response,9 showed partial response and 3 showed no change. The overall response rate was 78.6%. After intraaarterial chemotherapy, 5 patients underwent radical vaginectomy;7 patients recewed radiotherapy and 6 of them showed complete response at the end of radiotherpy. Conclusion Intraarterial chemotherapy is an effective method for primary vaginal carcinoma.$$$$
出处
《肿瘤》
CAS
CSCD
北大核心
2001年第5期384-385,共2页
Tumor
关键词
阴道肿瘤
介入治疗
顺铂
表阿霉素
治疗
Vginal neoplasm
ntraarterial chemotherapy
Cisplatin
Epirubincin
