摘要
目的 了解长期模拟失重状态下大鼠下丘脑功能活动状态 .方法 用 Fos和胶质原纤维酸性蛋白 (GFAP)的ABC法 ,分别检测 4周模拟失重大鼠下丘脑神经元和星形胶质细胞 (AS)的变化 .结果 二者表达仅见于室旁核尤其大细胞部、视上核和视交叉上核 ,而其它部位未见表达 ;AS胞体变大、突起增粗增长 .结论 下丘脑这些核团参与了对长期失重的反应 ,且可能与加压素分泌增加有关 .
AIM To research the functions of rat hypothalamus under long term simulated weightlessness condition. METHODS By using anti Fos and anti GFAP immunohistochemical ABC methods, we observed changes of hypothalamus neurons and astrocytes in 4 wk simulated rats. RESULTS Expressions of Fos and GFAP positive cells were only found in paravetricular nuclei of the hypothalamus, especially in mango cellular part, supraoptic nuclei and suprachiasmatic nuclei, with negative reaction in other areas. The reactive astrocytes were featured with hypertrophy of the cell body and cytoplasmic processes. CONCLUSION These nuclei in hypothalamus may participate in the reaction to long term weightlessness, and probably be associated with increased secretion of vasopressure.
出处
《第四军医大学学报》
北大核心
2001年第14期1268-1271,共4页
Journal of the Fourth Military Medical University
关键词
下丘脑
基因
FOS
神经胶质原纤维酸性蛋白
失重
hypothalamus
gene, Fos
glial fibrillary acidic protein
weightlessness simulation
