摘要
为评价亚胺培南、帕尼培南与美罗培南的体外抗菌作用 ,用琼脂双倍稀释法测定从我院重症监护病房分离的 2 30株革兰氏阴性菌的最低抑菌浓度 (MIC) ,并采用抑制剂增强的纸片扩散法测定大肠埃希氏菌和肺炎克雷伯氏菌超广谱 β-内酰胺酶 (ESBL s)。结果 ,5 0株肺炎克雷伯氏菌和 17株大肠埃希氏菌中的ESBL s阳性率为 6 1.2 %。三种碳青霉烯类对阴沟肠杆菌、肺炎克雷伯氏菌、大肠埃希氏菌、不动杆菌等都具有高度的抗菌活性 ,且对产 ESBL s菌株保持高度的抗菌活性。对嗜麦芽黄单胞菌高度耐药。
Objective: To evaluate the in vitro antibacterial activity of imipenem, panipenem and meropenem. Methods: The minimal inhibition concentrations (MICs) of 230 Gram negative isolates from ICU of our hospital were determined by standard agar dilution method, and extend spectrum β lactamases (ESBLs) produced by Escherichia coli and Klebsiella pneumoniae were detected by inhibitor potentiated disk diffusion test. Results: The incidence of ESBLs in E.coli and Klebsiella pneumoniae was 61.2%. Three carbapenems were highly active against Enterobacter cloacae, Klebosiella pneumoniae, Escherichia coli, Acinetobacter and also against the strains producing ESBLs, while Xanthomonas maltophilia was highly resistant to three drugs. Conclusion: Carbapenems are the proper choice for the patients in ICU infected by multiresistant bacteria.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2001年第4期283-285,共3页
Chinese Journal of Antibiotics
