摘要
目的 研究乙型肝炎病毒 (HBV)感染与肾小球肾炎的关系 ,探讨HBV复制在HBV相关肾炎发病中的作用。方法 对 338例经肾穿刺证实的肾炎患者的临床病理表现和病毒血清学特点进行分析。结果 HBV相关肾炎占肾炎总数的 5 .3%。在血HBsAg(+)的肾炎患者中 ,HBV相关肾炎发病与血HBeAg相关 (P <0 .0 5 ) ,与血清HBVDNA含量 (bDNA)显著相关 (P <0 .0 1)。分支链DNA(bDNA)阳性率明显高于HBeAg阳性率 (P <0 .0 5 )。结论 bDNA是反映HBV复制的最佳指标。HBV相关肾炎与体内HBV复制程度密切相关 ,HBV在体内大量复制 ,可能通过循环中的病毒抗原沉积于肾脏和肾脏中该抗原原位表达而致病。
Objective To study the relationship between HBV infection and glomerulonephritis, and to investigate the etiological role of HBV replication in HBV associated glomerulonephritis. Methods Clinical features and viral serology of 338 patients with glomerulonephritis diagnosed by renal biopsies were analyzed.Results Among all patients 37 were HBV associated glomerulonephritis, the incidence being 5.3% in this study.It was an important type of secondary glomerulonephritis in China. There were two correlations among HBsAg carriers suffered from glomerulonephritis: one was between HBV associated glomerulonephritis and serum HBeAg positivity ( P <0.05) and the other was between HBV associated glomerulonephritis and quantitation of serum HBV DNA by bDNA assay( P <0.01). The positivity of bDNA assay was significantly higher than that of HBeAg.Conclusion The bDNA assay was the best indicator of HBV replication. The results suggested that HBV associated glomerulonephritis was strongly correlated to the degree of viral replication. Large amount of replication of HBV might be causative to renal lesions through deposition of circulatory HBV antigens in kidney and thus expressed in situ.
出处
《上海医学》
CAS
CSCD
北大核心
2001年第11期674-677,共4页
Shanghai Medical Journal
