摘要
涂敷直链淀粉 三 (3,5 二甲基苯基氨基甲酸酯 )于自制的球形氨丙基硅胶上 ,制备了手性固定相。用该固定相直接拆分了一系列外消旋联苯类保肝药物 ,考察了一系列伯醇 (乙醇、正丙醇、正丁醇 )和异丙醇等流动相改性剂对保留和立体选择性的影响 ,讨论了固定相对样品的作用机理。
A chiral stationary phase(CSP) was prepared by coating amylose tris (3,5 dimethylphenylcarbamate) onto aminopropylated spherical silica gel The enantioselective chromatographic separation of a series of biphenyl compounds with antihepatitis activity was performed for the first time on CSP The effect of alcohol modifiers in mobile phase was investigated The mobile phases used in the study were hexane modified by ethanol, 1 propanol, 1 butanol or 2 propanol It was found that the retention times and the separation of the enantiomers of biphenyl compounds on the CSP were dramatically influenced by the nature of alcohols in the mobile phase, and the best alcohol modifier for some compounds was ethanol. The interaction between the stationary phase and samples was also discussed.
出处
《色谱》
CAS
CSCD
北大核心
2001年第5期443-445,共3页
Chinese Journal of Chromatography
基金
中国科学院重点基金资助课题 (批准号 :KY95 SI 2 0 5 )
