摘要
目的 检测高血压病患者及正常人的内皮依赖性血管舒张功能 ,并观察高脂煎炸食物及富含精氨酸食物对其影响。方法 31例高血压病 (EH)患者及 10例正常人进入研究 ,均于基础状态接受高脂餐负荷试验 ,采用高分辨率血管超声在彩色多普勒能量图显像 (CDPI)于空腹及餐后 4h检测肱动脉的血流介导的内皮依赖性血管舒张功能。之后 14例EH患者及 10例正常人接受富含精氨酸食物 ,另外 17例EH患者接受普通饮食 ,1周后重复高脂餐负荷试验及空腹、餐后 4h内皮依赖性血管舒张功能的检测。结果 高血压病组及正常组在未进食富含精氨酸食物前的高脂餐后的内皮功能显著降低 ,高血压病组较正常组降低更加明显。 (EH餐前后 :12 .9%± 5 .7%和 3.3%± 5 .2 % ,P <0 .0 1;NOR餐前后 :16 .5 %± 9.4%和 5 .5 %± 5 .9% ,P <0 .0 5 )。进食富含精氨酸食物 1周后 ,正常组高脂餐后内皮依赖性血管舒张功能升高 ,但差异未达显著 (5 .5 %± 5 .9%和13 .1%± 4.1% ,P >0 .0 5 ) ,而高血压病组高脂餐后内皮依赖性血管舒张功能非常显著的升高 (3 .3 %± 5 .2 %和13 .3 %± 5 .7% ,P <0 .0 1) ,未食用富含精氨酸食物的高血压组 1周后复查的高脂餐后内皮依赖性血管舒张功能仍然显著降低 (6 .0 %± 5 .0 %和 5 .8%± 4.1% ,P >0 .0 5 )。?
Objective To measure the endothelium dependent vasodilatation in patients with essential hypertension (EH) and normal subjects (NPs) and to observe the effect of foods rich in high fat or arginine on endothelium dependent vasodilatation. Methods Thirty one patients with EH and 10 NPs were studied.All of them received a single high fat meal, the endothelium dependent vasodilatation was assessed in the brachial artery by high resolution ultrasound technique with Color Doppler Power Imaging at fasting and 4 hours after high fat meal. And then, 14 patients with EH and 10 NPs received foods rich in arginine while another 17 patients with EH received, the ordinary foods. Endothelium dependent vasodilatation was assessed again after 1 week of eating foods rich in arginine or foods as usual.Results After high fat meal, the endothelium dependent vasodilatation in patients with EH and NPs was significantly reduced before eating foods rich in arginine [EH:(12.9±5.7)% vs (3.3±5.2)%, P <0.01; NPs:(16.5± 9.4 )% vs (5.5±5.9)%, P <0.05]; and after 1 week of eating foods rich in arginine, the endothelium dependent vasodilatation after high fat meal of NPs increased, but no significant difference was observed [(5.5±5.9)% vs ( 13.1 ± 4.1)%, P >0.05], However, it was significantly increased in patients with EH [(3.3±5.2)% vs (13.3±5.7)%, P <0.01], Endothelium dependent vasodilatation of patients with EH without having foods rich in arginine after 1 week wasn't significantly different from that after high fat meal [(6.0±5.0)% vs (5.8±4.1)%, P > 0.05 ].Conclusion Endothelium dependent vasodilatation after high fat meal in patients with EH and NPs reduces obviously, but it can be corrected by foods rich in arginine.
出处
《上海医学》
CAS
CSCD
北大核心
2001年第10期618-621,共4页
Shanghai Medical Journal
