摘要
本文报道IL-2对HFT的增殖反应性。12.5U/ml的IL-2能诱导HFT明显的增殖作用,与IL-2反应的高峰在培养后的第三天,细胞密度以1.25×10~6/ml为宜。这种增殖作用与培养体系中是否含有血清成分无关。这些提示,在HFT上表达有IL-2受体。这对人类个体发育的认识将是重要的,且对HFT的有关应用具有参考意义。
The proliferative responses of IL-2 to human fetal thymocytes (HFT) were studied in this paper.At 12.5U/ml of IL-2, the proliferation of HFT was obvious and similar to that induced by the same units of rIL-2. The peak response occurred at days 3. An amount of about 1.25×108/ml cells is optimal. However, the responsibility is not relative to present calf serum or absent in the culture systems. The results suggest that IL-2 receptors may have an expression on the HFT surface, and the proliferation of the HFT in vitro in response to IL-2 was detected by 3H-thymidine incorporation. It is significant to understand individual growth in the human race and to devclope some uses in HFT.
出处
《免疫学杂志》
CAS
CSCD
北大核心
1991年第1期26-28,共3页
Immunological Journal
关键词
IL-2
人胚胎胸腺细胞
增殖作用
laterleukin 2 (IL-2) , Human fetal thymocyte, Proliferative response
