摘要
目的:研究N-乙酰半胱氨酸(NAC)对缓解期肺心病的抗氧化和免疫调节作用。方法:38例肺心病缓解期患者予NAC 600 mg.po,qd,共6mo。比较治疗前和治疗后1,3,6mo血清MDA,CD3,CD4,CD8水平,并与健康志愿者(对照组)比较。结果:与对照组比较肺心病缓解期MDA明显升高(P<0.05),而CD4显著降低(P<0.01);经NAC治疗后MDA、CD4分别于1,3mo月恢复正常。结论:NAC能降低肺心病缓解期患者的过氧化物水平,捉高免疫力,有可能减少急性加重的发生。
AIM: To study the effect of anti-oxidation and immunity adjustment of N-acetylcysteine (NAC) on patients in remission stage with cor pulmonales. METHODS: Thirty-eight patients in remission stage with cor pulmonales were treated with NAC 600 mg, pa, qd, and the serum MBA, CD3, CD4, CD8 contents between treat group before and after 1, 3, 6 mo after treatment as well as control group was com- pared, to observe frequency of the exacerbation in 6 mo. RESULTS: Serum MDA content was higher (P< 0.05), CD4 content was lower (P<0. 01) in patients in remission stage with cor pulmonales than that in control group; content of MDA and CD4 returned to normal level after 1st, 3rd month with NAC treat- ment. The frequency of the exacerbation was decreased significantly. CONCLUSION: NAC can reduce the lipid peroxide, improve the immunity function and decrease the frequency of the exacerbation in patients with cor pulmonales in remission stage.
出处
《中国临床药学杂志》
CAS
2001年第5期275-276,共2页
Chinese Journal of Clinical Pharmacy