摘要
目的 :探讨抗Sm抗体、抗双链DNA抗体、抗核抗体联合检测对SLE的诊断意义。方法 :用免疫印迹法 (IBT)、胶体金斑点免疫渗滤法 (DIGFA)、间接免疫荧光技术 (IIF)检测抗Sm抗体、抗双链DNA抗体、抗核抗体。结果 :6 7例SLE患者中 ,抗Sm抗体、抗双链DNA抗体、抗核抗体阳性率分别为 2 9 9%、 6 5 7%、 82 1% ,三者综合阳性率 97 0 % ,明显高于单项检测阳性率 ,经统计学处理 ,有显著性意义 (P <0 0 1)。其中 9例抗Sm抗体、抗双链DNA抗体均为阴性 ,而抗核抗体为阳性 ;1例抗双链DNA抗体为阳性 ,而抗Sm抗体、抗核抗体均为阴性。结论 :联合检测可避免因单项检测出现的漏诊情况 ,起到相互补充、相互印证 。
Objective:To investigate the diagnosis significance of anti_Smith antibody?anti_double stain DNA antibody and anti_nuclear antibody examining the systemic lupus erythematosus jointly.Methods:Using the western blotting method?the collaurum macular immunofiltration and the indirect immunofluorescence,the anti_Smith antibody?the anti_double stain DNA antibody and the anti_nuclear antibody were examined.Results:Among 67 cases,the positive rates of the anti_Smith antibody?the anti_double stain DNA antibody and the anti_nuclear antibody were 29 9%?65 7% and 82 1% respectively.The summing_up positive rate was 97 0%,which was obviously higher than individual examination.By statistics,there was statistical difference( P <0 01).Conclusion:The combined examination can avoid leaking diagnosis,replenish and confirm each other for the definite diagnosis of the systemic lupus erythematosus.
出处
《汕头大学医学院学报》
2001年第3期203-204,共2页
Journal of Shantou University Medical College
关键词
系统性红斑狼疮
抗核抗体
抗SM抗体
抗双链DNA抗体
诊断
Systemic Lupus Erythematosus
Anti_nuclear Antibody
Anti_Smith Antibody
Anti_double Stain DNA Antibody
