摘要
观察温病经典方剂青蒿鳖甲汤抗慢性乙型肝炎肝纤维化的作用,寻找抗肝纤维化的有效方剂。方法:选择慢性乙型肝炎肝纤维化患者143例,随机分为青蒿鳖甲汤治疗组75例和大黄(?)虫丸对照组68例。进行疗程相同的对照治疗。观察项目为血清透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、层粘蛋白(LN)、Ⅳ型胶原(Ⅳ-C)。结果:治疗组HA、PCⅢ、LN、Ⅳ-C均有明显下降,两组比较有显著性差异(P<0.01)。在中医辨证施治方面,治疗组对各证型的肝纤维化均有显著疗效(P<0.01);而对照组较适合于气滞血瘀型的肝纤维化患者。结论:青蒿鳖甲汤联合辩证用药的抗纤维化作用比大黄(?)虫丸疗效更好,是一种抗肝纤维化较好的治疗方法。
To observe the efficacy of Qinghao Biejia Decoction of the famous prescription of seasonal
febrile diseases in treating liver fibrosis of chronic hepatitis B, to seek the effective prescription against liver fibrosis. Methods: 143 liver fibrosis of chronic hepatitis B patients were randomly divided into group A and B. 75 patients in group A received Qinghao Biejia Decoction and 68 patients in group B received Dahuang Zhechong Pill for same weeks. The effects were observed on the change of hyaluronic acid (HA), pro-collagen Ⅲ (PCⅢ)、laminin (LN) and Ⅳ collagen ( Ⅳ-C). Results: Levels of serum HA, PC Ⅲ , LN. Ⅳ-C in the group A declined more obviously than that of group B, the defference was significant (P<0. 01). In determination of treatment bsaed on the differentiation of symptoms and signs of traditional Chinese medicine, the obvious efficiency were observed for all kinds of syndromes in treating liver fibrosis (P<0. 01). The control group was observed for syndrome of stagnation of Qi and blood stasis. Conclusion: Qinghao Biejia Decoction and differentiation of symptoms and signs are more effective than Dahuang Zhechong Pill in treating liver fibrosis. It is a good treating method against liver fibrosis.
出处
《中西医结合肝病杂志》
CAS
2001年第6期324-326,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
