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二氧化硫对小鼠不同组织器官的氧化损伤作用 被引量:105

Oxidation damage of sulfur dioxide on various organs of mice
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摘要 对小鼠进行SO2 染毒处理 ,测定吸入SO2 后 6种脏器 (脑、肺、心、肝、脾、肾 )的抗氧化酶活性及抗氧化物质 (GSH)和脂质过氧化作用 (LPO)的水平 .结果表明 ,(1)SO2 吸入引起所有所试脏器抗氧化酶、超氧化物歧化酶 (SOD)和谷胱甘肽过氧化物酶 (GSH Px)活性降低 ,GSH含量下降及脂质过氧化作用升高 .(2 )SO2 对不同脏器引起的氧化损伤程度不同 ,存在器官差异 ,尤其以脑、心、肝、肺更为严重 .(3)雌、雄有一定差别 .由此得出结论 :(1)通过过氧自由基引起组织细胞的氧化损伤可能是SO2 毒理作用的主要机制 ;(2 )SO2 是一种全身性毒物 。 The mice were treated by SO 2 inhalation for 4 h/day × 7 days, and then activities of Cu,Zn superoxide dismutase (SOD) and glutathione peroxidase (GSH Px), levels of reduced glutathione (GSH) and lipid peroxidation, of various organs (brain, lung, heart, liver, spleen, and kidney) were measured. The results showed that (1) SO 2 inhalation decreased the activities of SOD and GSH Px, also decreased levels of GSH, but increased levels of lipid peroxidation in all mouse organs tested; (2) levels of oxidation damage caused by SO 2 were different in various organs , especially oxidation damages of brains, hearts, livers and lungs of mice tested were more serious; (3) Some sex differences were also found. It was suggested that (1) The primary mechanism of toxicological role on mammalian cells by SO 2 exposure may be that oxidation damages of lipid and other biomacromolecule are caused by SO 2 producing reactive oxygen species; (2) SO 2 is a systemic toxin, some damages and diseases of various organs and tissues may be caused by SO 2 exposure.
出处 《环境科学学报》 CAS CSCD 北大核心 2001年第6期769-773,共5页 Acta Scientiae Circumstantiae
基金 国家自然科学基金资助 (No .30 0 70 6 47) 山西省自然科学基金资助
关键词 二氧化硫 氧化损伤 脂质过氧化作用 全身性毒物 小鼠 组织器官 大气污染 生物监测 sulfur dioxide oxidation damage lipid peroxidation systemic toxin mouse
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